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- To screen for coagulation deficiency
- To investigate the effects of liver failure and DIC
- To measure the response to oral coumadin anticoagulant therapy
- In oral anticoagulant therapy, the therapeutic goal is a prothrombin time 2 times the normal value.
- International normalized ratio (INR) provides a standardized measurement of the response to oral anticoagulant treatment. INR is 2.5 to 3.5 in therapeutic range.
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- Excess anticoagulant therapy
- Deficiency of fibrinogen, prothrombin, Factor V,VI or X
- Liver disease
- Vitamin K deficiency
- DIC
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- Lipemia
- Hemolysis
- Inadequate blood sample
- Prolonged delay before analysis is performed
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