Glucagon Plasma 50-100 pg/ml To assess in suspected pancreatic tumors, chronic pancreatitis, familial hyperglucagonemia Acute pancreatitis Diabetic Ketoacidosis Glucagonoma Hypoglycemia Parasympathetic stimulation Pheochromocytoma Renal failure Stress Sympathetic stimulation Chronic pancreatitis High fatty acid levels Hyperglycemia Insulinoma Stress Prolonged fasting Radioisotope scan within 2 days Medications (catecholamines, insulin, glucocorticoids) It is produced and secreted by the alpha cells of the islets of Langerhans of the pancreas.