Fibrinogen (Factor I) Plasma Adult: 200-400 mg/dl To help diagnose Bleeding Disorders, including afibrinogenemia, DIC, fibrinolysis Sepsis infection Malignancy Inflammation Traumatic injury Hereditary afibrinogenemia Hypofibrinogenemia Severe liver disease DIC Heparinization Pregnancy (third trimester) Recent surgery Inadequate amount of specimen Hemolysis Coagulation of the specimen